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Our Program

BILE ACIDS & SEQUESTRATION

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  • Bile acids are efficiently reabsorbed by the ileal bile acid transporter mainly at the terminal ileum when most of their roles in the gut have been carried out

  • Bile acids promote secretion of water and electrolytes by the human colon

  • Bile acid malabsorption is involved in the pathogenesis of diarrhea and steatorrhea in patients with ileal resection

  • Bile acid malabsorption can be addressed with the effective sequestration of the bile acid

VALUE OF TARGETED DELIVERY

  • Bile acid sequestrants are not absorbed by the gut

  • However, they degrade in the hostile gut environment

  • In order to safely and effectively sequester bile acid at the terminal ileum, the delivery of the sequestrant needs to be targeted

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Pipeline

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